Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin
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چکیده
منابع مشابه
KLK 11 ( Kallikrein - related peptidase 11 )
Three alternatively spliced variants have been described in the literature: including isoform 1, isoform 2, and isoform 3. Isoform 1 is preferentially expressed in the brain and it encodes a protein of 250 amino acids. Isoform 2 and isoform 3 are mainly expressed in the prostate. Compared to isoform 1, isoform 2 has additional 32 amino acids at the N-terminus and isoform 3 contains extra 25 ami...
متن کاملKLK 7 ( kallikrein - related peptidase 7 )
Five variant mRNA transcripts have been identi-fied. These include transcripts using different 5' untranslated regions (UTRs) including exon 1 deletions, and transcripts using different 3'UTR regions. Using rapid amplification of cDNA ends (RACE) different KLK7 5'UTR sequences were identified from RNA extracted from pancreas, skin and ovarian cells, suggesting the expression of tissue specific ...
متن کاملKLK 5 ( Kallikrein - related peptidase 5 ) Yousef GM
Five alternatively spliced variants have been identified for the KLK5 gene. These variants differ in the number and length of the 5' untranslated exons and/or the last two coding exons. Tissue-specific expression of these variants is regulated by multiple promoters located in the first exon of each isoform. KLK5 splice variants were found to be differentially expressed, at the mRNA level, in ov...
متن کاملAtlas of Genetics and Cytogenetics in Oncology and Haematology KLK 8 ( kallikrein - related peptidase 8 )
Human KLK8 was originally cloned (Yoshida et al., 1998) as the human ortholog of the mouse brain protease neuropsin (Chen et al., 1995). Using Northern blot and RT-PCR analyses, it has been shown that KLK8 is expressed mainly in breast, cervix, esophagus, skin, ovary, testis, salivary glands and vagina. Adrenal, brain, colon, heart, kidney, lung, muscle and prostate also express KLK8 mRNA at me...
متن کاملThe New Kallikrein-like Gene, KLK-L2
Since in rodents the kallikreins are represented by a large multi-gene family, the restriction of this family in humans to three genes is somewhat surprising. In an effort to identify new human kallikrein genes, we examined a genomic area of about 300 kilobases on chromosome 19q13.3-q13.4, a region that contains most of the currently known kallikreins. By using the positional candidate approach...
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ژورنال
عنوان ژورنال: Biological Chemistry
سال: 2018
ISSN: 1437-4315,1431-6730
DOI: 10.1515/hsz-2018-0108